A combination of super disintegrants, i. Highly volatile ingredients like ammonium hydrogen carbonate, ammonium carbonate, benzoic acid, camphor, naphthalene, urea, urethane and phthalic anhydride may be compressed along with other excipients into a tablet.
Pre weighed sample of 6 tablets was placed in a friabilator, which was then operated for revolutions. By freeze drying the drug in a matrix, consisting of gelatin the Zydis tablet was produced. Drug Development Ind Pharm; 30 5: S Nail, L Galtin.
The powder equivalent to the average weight of tablets was weighed and extracted, and concentration was determined by measuring absorbance at Wetting time Five circular tissue papers of 10 cm diameter were placed in a Petri dish with a cm diameter.
J Swarbrick, JC Boylan. The presence of porous structure in the tablet matrix is the key for rapid disintegration of MDT 5, 6. Article for carrying chemicals. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. In all formulation mannitol was common diluents.
All other reagents were of analytical grade. Cinnarizine mg tablets each containing 25 mg of drug were prepared. The time in seconds taken for complete disintegration of the tablet with no palatable mass remaining in the apparatus was measured in seconds.
All the formulations were evaluated for their characteristics such as average weight, hardness, wetting time, friability, content uniformity, dispersion time DTand dissolution rate. Disintegration time in between 49 to 54 second the results indicate that disintegration time of tablets is within 1 minute.
Int J Pharm ; All the formulated tablets met the pharmacopoeias standard of uniformity of weight, percentage friability, thickness, and drug content.
Encyclopedia of pharmaceutical technology, Marcel Dekker Inc. When the freeze drying is complete, then on the blister sealing machine the aluminum foil packing is applied. Wetting time The tablet was placed at the centre of two layers of absorbent paper fitted into a dish. This volatile stuff is so removed by sublimation go forthing behind a extremely porous matrix.
Design of fast dissolving tablets. Tablets prepared by direct compression mainly affect the dissolution and disintegration process of the tablet. Tablets were rotated at 25 rpm for 4 minutes or up to revolutions.This research was to formulation and evaluation of fast dissolving tablets of Ramipril using direct compression technique (effervescent) with sodium bicarbonate, mannitol, polyvinylpyrrolidone, citric acid.
Mouth dissolving tablets can be prepared by direct compression, wet granulation, moulding, spray drying, freeze drying or sublimation methods (Biradar SS., ). Mouth dissolving tablets dissolve rapidly in the saliva without the need for water, releasing the drug (Kaushik D., ). Table 1: Formulation and evaluation of mouth dissolving tablets prepared by different technique.
For tablets prepared by effervescent method, specified quantity of cinnarizine, mannitol, Avicelaspartame, talc and magnesium stearate were weighed accurately and passed through 60 # screen. Mouth dissolving tablets of cinnarizine were prepared by effervescent, superdisintegrant addition and sublimation technique by direct compression method.
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS PREPARED BY DIFFERENT TECHNIQUE. Various methods were tried for formulation of mouth dissolving tablets. Formulation And Evaluation Of Mouth Dissolving Nimesulide Tablets Biology Essay Abstraction: Mouth fade outing tablets has figure of advantage viz., faster oncoming of action, elegance, easiness of disposal, easiness of fabrication, easiness of storage and conveyance.
formulation and evaluation of mouth dissolving tablets of omeprazole Objective: The aim of present study is to formulate mouth dissolving tablet of omeprazole, the drug will be directly absorbed into systemic circulation through buccal mucosa and lead to produce immediate action.Download